Agaricus bisporus and A-V-8R give the most realistic impression as far as I'm concerned.
My contribution------
Unsocial hours.
Lack of proper sleep.
Bad rostering.
Destroyed social life.
Poor diet.
Away from home.
Stressful.
Wasteful.
Dangerous.
As for the comment "I've been flying jets for four years and it's OK", ask him again in another four years, with twenty five more to go !
IMHO, or more accurately, IMEO (E=experienced it for 20+ years).
Problem is, one gets locked in financially, missus in a job, kids at school, with little else one is qualified to do.