I guess I should clarify my opinion (yes my opinion, nothing more).
Yes, the V22 was intended to replace the USMC CH53D/CH46 mission.
However,
The 53 is classified by the manufacturer and all users (outside the USMC) as a heavy lift helicopter, even the 53D. Now I would argue that the 53D is a heavy lift airframe used for a "medium lift" role in conjunction with the CH46 for the USMC, seeing as how the former has approximately double the MGW of the latter. (Was the 53D "medium lift" in the Marines' books prior to the introduction of the CH53E?)
The simple fact that the USMC was using the CH53D as a medium lift asset does not make it something inherently "medium lift" for everyone, which is why I would not expect Israel to replace their 53s with V22, as they are using them as intended/designed workhorse heavy lift assets, with missions catering to that performance no doubt.