Hi,
I have emailed Vueling and here is the response:
'
Thank you for contacting Vueling. In response to your e-mail, we would like to indicate that, currently, it is not planned to add Southampton as a Vueling destination anytime soon.
As of now, the only England destination available for booking, from several spanish cities, is London. However, a new route, Barcelona - Cardiff, is planned to start operating next spring, and is already available for booking to fly on dates between march and may 2012.
We can only recommend you to keep an eye on our website, www.vueling.com, and to subscribe to our newsletter to receive the latest news about routes and offers as soon as they appear.'
I guess that means, No, Vueling are not going to start flying to Sou.
Cheers
Steve