There was, and probably still is, a demonstration of this during the QHI course at RAF Shawbury. It was shown to all QHI students because someone had managed to crash a Gazelle whilst debriefing a student and flying cross controlled from the LHS.
Most people can hack it for a while, especially if control is handed over in a reasonably trimmed hover. However, once errors start to appear, the almost inevitable result is trying to hit the ground descending and moving backwards.
The natural reaction for a pilot is to try and get away from the ground by pulling up with the left hand to increase collective - this hand though is on the cyclic so it starts a rearward drift - then to counter the drift, the pilot tries to input forward cyclic with the right hand - this hand is on the collective which now goes down.
With practise, it is eminently possible to fly 'wrong-handed' - after all you could teach pilots that way from the start and it would be 'normal'.