Hmmm... Where to start?
I've had about a dozen flights in the 20 hour range, but I think my longest was this one at 21.6 hours from start-up to shutdown, including 20:55 actual time in the air.
The longest distance I've flown non-stop was 2650nm from Massachusetts to Shannon, Ireland. As a testament to the Mooney's fuel efficiency, I took on 0 gallons of fuel in Shannon (they don't carry avgas anymore) and flew another 1000nm+ to Vienna on the same fuel I took on in Mass. 3700nm on a tank of gas ain't too bad.
Other notables include this one at 2450nm non-stop,
which made for a very long week because it was only four days after this one:
One of the most memorable has to be a 17-hour flight in a Twin Otter from Hawaii to the Marshall Islands due to the fact the I had no autopilot, no heat, a GPS failure, and was surrounded by 1400 gallons of JetA.
Finally, one of the longest point A to point B flights (though there were stops en route) was this one at 12,410nm which required nearly 100 hours of total flying time