Eventually 200 to 209 Manchesters entered service, before production ended in November 1941. The aircraft was withdrawnm from service June 1942.
193 were operational. Of the 78 aircraft lost, 45 were non-operational losses of which 30 involved engine failure. Later on in its life the Manchester became a fairly effective aircraft once issues with the Vulture engines were resolved.
A good link to read: -
Lancaster History