BA B747-400,
Note: retired 2 years ago
Reduced thrust almost every time.
The exceptions being places like Mexico City and Jo'berg, where fuel requirements and payload combined with the density altitude often required virtually full thrust (JNB maybe 1.72 EPR vs 1.74 max, but near as the same thing).
Some places (like MEX, JNB, GRU) also use an Aft C of G optimisation technique to maximise RTOW and gain payload.
Sometimes using a short runway eg Chicago, Cape Town or to avoid a delay also, but even on a long flight ex Singapore, you would normally derate somewhat to reduce from full thrust allowing 20,000+ hours on wing commonly for the engines.