Yes, of course. The same principles apply. Up, down, left, right. Within the standard operational limits of airliner it's pretty easy.
That's speaking as someone who flew a E195 with a real yoke and FBW in the morning, and a 320 and a 767 sim in the afternoon.
However, to fly them with the precision and finesse you expect as an operational airline pilot flying your own type is slightly more of a challenge.