@Turbine D
It's not the occasional high-load stresses that bother me as much as the research into pressurisation cycles over time. When we went to jets made from aluminium, it turned out that we didn't know as much about how fatigue affects an aluminium pressure vessel as we thought. Hopefully the bods at all the manufacturers have got it right this time!
(That said, the Achilles' heel of the Comet 1 turned out to be fatigue cracks emanating from rivet holes aruond the windows - the 787 doesn't use rivets in the traditional sense)