Talking realistically when will you use a cloud as a referance? Usually when you are up amongst the clouds with limited views of the ground below.
Good VFR days with extensive views of the ground ahead and you will probably pick a small hill or a power station or town/village on track.
Up amongst the clouds you will be using conventional nav aids so the cloud fixing will probably be because you are tired of instrument/nav flying and decide to fly visually admiring the cloud scenes.
Realistically if you go off track flying to clouds you will soon go back on track using the navaids.
The other reason will be picking your way through weather and avoiding large CBs or for that fact even lumpy stuff like towering cumulus etc.
It is then a matter of picking the right areas to visually head to while reading the tops and bases of the clouds in front as well as whats likely to lie beyond.
In this second scenarion you will be all over the shop so will still rely on navaids to get back on track when the weather has been cleared.
Pace