The issue here is not so much the airplanes as the market that they were designed too. The 744F is setup to maximize Pacific payloads via an ANC tech stop, which has been the traditional approach.
CAO's HKG-CVG example would look very different if the 744F in question had it's horizontal stab tanks activated, which would increase both the fuel load and payload. And I suspect that if these non-stop Asia to North America freight flights become significant we will start to see 744Fs so configured. Or perhaps 744BCFs, since their lower MZFW and lack of a nose door better fit the market.