If it's true that Iberia/Nostrum had requested slots at BHX and taking in to account Spanair's plan to launch flights last year then you would think there is sufficient demand to fill anything from a CRJ to an A320 to Madrid
Not really, since Spanairs plans were cancelled due to dire lead in bookings.
I have no doubt we will eventually see a BHX-MAD, but, more than likely on a CRJ200 or -900.
Doha must surely be a main contender
Since QR's press release for the MAN 2nd daily stated that it would be used to carry Midlands pax, it seems they have no intention of starting BHX for a while yet
Helsinki, Warsaw, Kiev and Tel Aviv are other routes I'd like to think could come online
Id think that until hub carriers to the likes of MAD and LIS, those are very far fetched ideas.