I've done one in a 747-200F a few years back.
Much as described above, though I can't remember the details accurately. #4 engine was out (Damaged fan blades) and it took both of us to work all the controls for takeoff.
Note that we were extra careful during this takeoff as it was during the Dubai airshow and we knew there'd be hundreds of people there with video cameras - if that's not a recipe for disaster ..... !
FWIW the plane climbed away just fine and went straight to the high 20's for the initial cruise. We got up into the low 30's late in the cruise and were well ahead on the fuel burn as the 3-eng flight plan was very conservative. We cruised at something like M 0.74 or so.
(I think we actually passed an A320 ....)