WX will be yr single biggest concern. NEVER rely or trust ML's WX if yr VFR,any time of the year. As has been mentioned if ML are using the west rwy (27) then from yr route inbound in CTA (NE) forget planning anything other than coming in from the South. I'm not too sure the route yr planning from CB but there's some ugly terrain between CB & EN consider going via MNG where it's more friendly for a VFR driver down the 'eastern' lane (which really isn't as such) skirting along ML's eastern CTA boundary (you can always ask for direct clearance on the day anyway from the VFR entry points mentioned elsewhere in this thread) planning to enter EN via Albert Park lake or Station pier or Westgate Bridge, the latter the most popular & easiest route & you get to see the city & the bay whilst yr at it:-) The southern entry points as mentioned here are the most 'guaranteed' The 'Kilmore Gap' is another ugly place to watch out for in bad WX also.
There's a lot of variables when flying into an unfamil AD VFR that lies close to a major Airport. Wx, traffic on the day due that wx & the time you intend to arrive. A fair amount of VFR traffic transits that region East of ML OCTA so be alert. At the very least ALWAYS have an escape plan re another AD to land at if you get caught. Be well informed about Lillydale (have that at the back of yr mind)as that's a good spot to lob if yr caught due wx somewhere in the Eastern region of ML.
Enjoy the ride, the guys in EN twr are very helpful & have been known to 'suggest' the best route inbound if you care to call them on 125.1 whilst out there East of Melb
Wmk2