Clearly not every circumstance can be trained, programmed and simulated.
Once we accept that fact then we see a need for augmenting the resources on the flight deck in an emergency situation.
One solution would be an irridium satellite phone uplink with AF operations center supplying flight data and errors. It should also connect a voice channel. It would automatically connect when system errors reach a critical threshold level or manually activated.
It is easy to envisage a pilot receiving a call "This is AF operations: AF447 your a/c has 3 failed pitots and UAS. You are approaching stall, recommend immediate pitch down, side stick forward over...".
Satellite phone costs are cheap and air time would only be used in an emergency. There is presumably already an AF technical operations center which could be set up with the required telemetry systems.
We already see ECAM telemetry. This needs to be taken to the next logical level.