Why does a 777/MD11 make more sense? The MD11 doesn't have the capacity of the 777, and probably can't come close to the range of a 777 with a lighter load...
FedEx hauls mainly small packages, not heavy freight. AeroLogic does the same for DHL. I don't know what LH's plans are.
The package and freight markets are significantly different. As others have already pointed out, there is significant advantage with the 744F for heavy/outsize freight. The 744 can carry 108T HKG-ANC now, and lighter loads to 7600+ NM (e.g., 45T HKG-CVG).
Think you misunderstood me - my point is it doesn't make sense comparing the 777 with the MD11.
AeroLogic is flying for LH now on their week-end trunk routes to the US and Far East, and the aircraft seems to be doing the job they're asking of it.
As for the last bit, so can a 777F (if you consider 107.5 tons near enough). Except it would probably be able to haul closer to 55T HKG-CVG, and it wouldn't be fuel limited.
... and I'm still not convinced 4 x GENx will burn less than 2 x GE90. That would as good as make the 777F obsolete, whereas in reality it's selling pretty damn good.