I came across a good extended rule of thumb, which I have been testing out extensively using the calibrated breathalyzer at work, and I'm pretty confident with:
8 hours bottle to throttle if you've had a couple of drinks, BUT
12 hours bottle to throttle if you've had a lot (should that be 12 hours Bender to fender???).
If you can't remember when you stopped drinking, this automatically qualifies you for the 12 hour rule and a conservative application thereof.