Lufthansa Twenty-Two Twenty-Eight is less preferable than the rather dissimilar Niner-Four-Charlie
In simple terms there MAY be similar 4 figure callsigns.E.G Lufthansa 2226 or 2238 or 2218 which ,in a busy scenario,may end up taking each others calls/instructions. The business of ATC is all about minimising risk. We use the alpha numeric callsigns to attempt to squeeze that part of the risk out of the system. Whilst the 94HC type callsign may seem unweildy it is easier to use than Lufthansa TWO TWO TWO AIGHT.