I have had a couple of 380 trips -Emirates, both times comnnecting to a 777-300 so could make some immediate comparisons
Noise or lack of it is very noticeable but so is the cabin conditioning- no stuffy nose ehadache at end of trip -not quite freshas a daisy but much much betetr than on all other long hauls I have done.
I should confessI am not a triple 7 fan i find them noisy, have poor cabin conditioning, not enough fresh air I assume. To me theyalso have a horrible wallowing ride and a step backwards from the mighty 744 DC10 and best of al the Trsitar.
So until maybe the 787 appears the 380 for me is in a league of its own comfort wise.