9.G:
When accepting direct to clearance the obstacle clearance responsibility rests with the PIC, I wouldn't descent below MEA unless radar vectored.
Caveat: I am speaking only of U.S./FAA procedures. When ATC initiates a descent clearance below MEA, that becomes a direct clearance and ATC is clearly responsible for terrain clearance. That does not negate, however a pilot check/verification at an unfamiliar location.
In other jursidictions, especially the mountainous areas of Latin America such operations probably won't occur, but if they do pilots are best left to not accept them.