I think the time of the flying battle ships Orions, Atlantics Nimrods is gone.
Lean & mean is the future.
I remember looking at the internal navigation package of P3C, with all the gyro's etc. In the cockpit there was also a little handheld GPS device. Comparing the costs was useless, guess which one was by far more accurate and reliable (everything was still connected to the big one though) . Same for the big central processing units.
Future processing and interpretation will be automated further and done by specialists in well equipped ground stations (or at home, or wherever they are...), looking over the shoulder of the crew & giving / discussing their inputs). Merging it with all other info from many other sources.