I am using Matrox triple head 2 Go and it works well usually. My problem is with one of the ATDs that does not allow me to run the mouse cursor directly between the main display and the secondary display (instrument panel). I don't think it has anything to do with the Matrox unit.
I am using an alienware computer at work and I found if I move the position of the monitors on the resolution screen it changes the way the mouse moves. I will give that a try when I get back to look at the problem computer. Still looking for answers for the MSX Save problem...