No in flight break ups that I'm aware of.
In the case of the Spitfire the wing loading went from 24lb/sq ft on the Mk 1 to just over 42lb/sq ft on the Seafire 47. MK 1, 5820 LB TOW, the MK 47, 12,500 lb overload TOW. To quote Jeffery Quill who was responsible for much of the development test flying of the F.37/34, the equivalent of the MK 1 carrying 32 airline pax, each with 40 lb of baggage.
Yes there were differing wings fitted as the aircraft was developed but these figures sure are a testament to the original design.