tistisnot,
Having flown one 76 or another across the US perhaps 20 times, just a few tips - since the aircraft is a great cross country machine, they are hardly necessary.
I suggest following the weather, jump the mountains where the ceiling allows. Once east of the rockies, punch south by the Mississippi river so you avoid the Alleghenies and just turn the corner at Tallahassee.
Stop at Kansas City and eat at Oklahoma Joe's Barbeque, then be sure and grab the oysters in Apalachicola FL.
Tips for cruise: Go up, as long as the winds are favorable, which they should be going west to east. Cruise at 7000 to 9000, set the fuel flow/torque so you get top milage. Use the trick of setting up a steady cruise at altitude, and then trim to 2 airspeeds and note the power/fuel flow to get the optimum. At each speed, just divide the TAS into the total fuel flow (Lbfuel/Hr divided by NM/Hr = Lbfuel/NM) so you can see how many pounds of gas takes you 1 mile. Pick the best speed, the lowest fuel per mile, and replan your gas stop if you can go 50 miles past. You should get numbers like 5 lb/NM or so, 4 Lb/NM for an A or A+. With a full bag of gas (1850lbs) you should be able to make 300 to 320nm between stops. On the Flightcase Planning Chart, that is the length of a typical ball point pen.
Never take the tower suggestion to park in the southeast ramp far from the pumps like skidded helicopters, you are a first class citizen, taxi up to the main flight line with bottom collective like a good neighbor
Never buy a McDonald's shake at the place across the street and then launch off to the sky with it on the center console while you munch a Big Mac, unless you want vanilla shake all over the radios as the entrapped air expands just like they told you in flight school!
File and fly IFR wherever it seems ok, the bird can certainly handle it. Have a blast, it is a fun flight!.