It depends on where you are coming from. Have you got a PPL and the IMC Rating, or just a PPL?
In Class G you can fly anywhere. The route chosen depends on your navigation method; normally one would choose to route via VORs because VOR/DME makes a good backup for a GPS, but often there is no VOR (or NDB) there so one can pick up airways intersections (they are also in the GPS database so they are handy). One should never use user waypoints in a GPS, due to the potential for data entry errors.