It happens...about 4 years ago a DC-9-32F lost a mainwheel on landing at FALA-it rolled up an embankment, across a taxiway, through a metal fence and through P&W's metal hangar wall.Missed a guy in there by metres. I've had a wheel fall off on the taxi-pax noticed as it wasn't properly off, just hanging by hydraulic lines and being dragged along, making sparks.
A Falcon Cargo 1900 in DXB had a wheel fall off in flight too...Its not that uncommon.
Oh and JEP-KQ never had 757s...