I think that the real problem for us 'simmers' would be the feel of the controls.
While a autoland might be possible, I feel quite certain that I would end up in an increased amount of self-induced oscilations if I ever tried a manual landing after just PC practice.
The 6-7 cm movement of a PC joystick can hardly compare to a flight yoke with feed-back and much more travel.
Equally, just how much do you kick the rudder pedal to compensate for cross wind etc ?
How exactly do you disengage the autothrottle - which would be a very nice thing to do when you flare (or touch down) ?
Autoland ? - maybe, manual: - probably a crash, but fairly close to the airport
The while a MCP can be emulated (and even bought) for a PC, the feel of the controls can never come across.
Some dead serious simmers have reported landing 777's in the Heathrow simulator (BA ?), but they are probably far between.
Regards
Michael