I had the same problem on a computer a few weeks ago. Reboot in safe mode didin't help. Couldn't open taskmanager either (to kill the process). The virus acted as a popupblocker and blocked taskmanager.
What to do:
press CTRL-ALT-DEL AND KEEP IT PRESSED !!!! This way task manager will open a few dozens of taskmanagerwindows at the same time and the blocker can't keep up with this. So you will have your taskmanager again.
Then go to processes and look for a process with some random letters/numbers with the .EXE extension. For example hjapgkwagnz.exe or qkwcrrwagnz.exe. Killing this process gave me control over the internet explorer again.
Then I went on the net, downloaded and installed malwarebytes, ran a scan and the program was removed.
Hope this helps and good luck
