I am amazed that on this thread people are talking about having to re-engine the A380 in light of this recent failure.
When the original 747 Classic started service in the early 1970s engine failures were common place. One of my colleagues lost 2 on one flight for separate reasons.
We live in a modern world where everyone expects technical perfection. Severe engine failures occasionally happen and will continue to do so.
As in the case of the severe engine failure on the Sioux City MD11 manufacturers learn from experience and no doubt RR will do so too.
From some of the comments on this thread you would think that this engine failure signals the death knell for the A380.