I have done Samos 09 twice on a 757 and didn't think of it as a difficult approach. It's one of the more interesting for sure.
One of the more difficult is probably Nassarsuaq Greenland on a 757. 1800 m Rwy landing with a downslope of -2.7% and the Rwy overrun would put you in the ocean. That was an interesting one as well.