For A-B flying or airborne science (two of my occupations), particularly in a noisy cockpit, they're the bees knees. Presumably the new Bose is slightly better, which may well make this a good time to grab a bargain.
For test flying, I never use ANR headsets - even at risk of increasing my personal (noise induced) stress levels, they filter out too much of the incidental noises that I need to be aware of. But that's what they're designed to do.
G