Could you imagine a incident in a A380 with just 2 pilots flying. Certainly that aircraft should require some sort of safety crew with proper first response equipment.
You mean like the 747 too or any other a/c with lots of people on board and only two flight crew?
Maybe there is a case for trained paramedics on board who also have had training in fire fighting etc? So as well as the fire risk they could attend to and diagnose sick passengers?