Bristol - tried before and never lasted long
Depends what you mean by 'long'.
The BHD-BRS route operated by Flybe (as Flybe and in its previous incarnations as far back as its Jersey European days) operated continuously for much of the 1990s (if not earlier) and on into this century until it was axed in November 2006 because, it was generally assumed, of the easyJet route to BFS.
Flybe had flown in competition with easyJet for about three years and in 2004 carried 76,000 passengers to BHD against easyJet's 232,000 to BFS which contrasts with 2009 when Ryanair carried 79,000 to BHD but easyJet had dropped to 163,000 to BFS.