They won't be aggrevated, they'll be dead, copping a .45inch copper jacketed hollow point between the eyes. Running at around 2540fps. Leaving a hole about the size of a tennis ball on the underside of its throat. Worked on a 4.5m salty and 700kg buffalo, and many a pig.....
Exactly what .45 cal pistol runs a velocity like this. The best I clould find was the .45 Winchester Magnum at 1900fps from a long 14 inch barrel, and that is with a light 185 grain bullet.
However the .458 Winchester Magnum (a rifle cartridge) gets close with 2500fps from a 25 inch barrel pushing a relatively light 350 grain bullet. This rifle by the way is an elephant slayer when loaded with 500 grain (about 1 oz) pills at approx 2100fps.
So tell us longrass what are you really packing, because clearly your hand gun does no where near 2540fps?
PS
All data collected from the Hornady Handbook of Cartridge Reloading.