nope - not with an airline - they did once hire pilots with as little as 250 hours, but that was when there was a major shortage.
Obviously, you could only be second in command.
@wiggums
.. adding to my last post...
i've been thinking about finishing the IR at this 141 school and then doing commercial part 61 - then go back to 141 and finish my degree (afterall, you do need a degree to get hired in the US).
So any info on your "theory" would help. I could save roughly 8000 USD doing it Part 61. :o
Oh, and i was wondering what ratings you have + hours and if ya dont mind me asking, what job.