Often no need for drugs per se. Salt has saved me unbelievable pain while down the route. A bad infection should be treated seriously, and the doc may prescribe antibiotics.
Run a Search: Me . . . and salt, and hanging upside down over the bath trying to force saline solution into the cavities.
Boiled water - don't fridge it, use when warm. Salt about the same as the sea. Invert head and shoulders. Fill cavity. Resist all temptation to laugh. Hold nose, and blow. And yes, some does go up the Eustachian tubes, so take care how hard you blow.
First time it squirts in . . . wonderful!! Most often can hear it squelch as it finally enters.
Upright, and sniff like hell. You'll know when it runs out. Repeat the procedure 'till both side pass the fluid freely.
My right tear duct (drain) allows the solution to squirt out. Never the left. Don't know why.
Last time we discussed this, someone said that you can still get the little glass tubes to help pour it in your nose.