What is your OS? A bit of a selection in your post! Malwarebytes is your first point of call. If that does not clear it, Super Anti-spyware and Norman 2010 if necessary. Run all in safe mode. Have you run Kaspersky in Safe?
If you still have it, find an AV that allows a boot scan - Avast for example, or the Avira boot scan download to burn a CD