I often see flights come up where there are also RPT flightsd available.
I have asked Angel Flight about these and their opinion is that it is just as much a charity for pilots wanting to fly. There seems to be no shortage of pilots lining up for the missions.
I suggested I'd chip in $100 for the RPT ticket as there is no way I'd fly a 4 hour round trip to take pax to the big smoke in a bugsmasha (as you suggest).
Cheers