Ok, without going into specifics of actual airports, I would go for an early one. Get out of A relatively light, and whilst transiting to B prepare for the stop. Then get on the ground with a light aircraft and get the aircraft turned with Flight Crew who aren't tired, thus less chance for error during the turn. Once enroute again, they will then get good rest on their breaks as they won't be mentally preparing for the turn. Overall safer IMHO.
However, the world doesn't work like that. The earlier stop may involve a technically more challenging destination where the risks are reversed. Thus, it should be down to the overall risk management decision by the crew.