This plane is obviously aimed at a market gap between the high end pistons and the TBM.
High end pistons have plenty of issues: engine management and mostly not making TBO if used to the full, high cockpit vibration levels compared with turbines, an awesome oxygen usage at FL200+, and one cannot compare the cramped cockpit of a Mooney with the cockpit of the E500. Sure one would not want to sit in a Mooney for 10hrs, but the ability to do a 1500nm nonstop flight in 9-10hrs is a plus, going to the further corners of Europe where the matrix of avgas/customs/opening hours gets pretty sparse. I've done three 6hr flights in the last 2 weeks, and for a good reason, avoiding loads of useless airports and useless fuel stops. Long range does have a market, even in a 2-seater. If you can do door to door, you will beat an airline anytime on the total trip time (especially Ryanair which makes you drive 20% of the GC distance in the opposite direction
).
The TBM costs about 5x more per mile than a high end piston. It goes about 2x faster. The despatch rate is probably 99%. And you pay nicely for that... But it still can't outclimb any respectable CB, so its ability to cross serious frontal weather enroute will not be much different to a plane whose ceiling is 25k. You will still probably be in IMC, using radar to find gaps. And a plane with a 25k ceiling will outclimb most non-frontal weather.
The Jetprop is very good but with the PT6 will cost more per mile (on the DOC) than the E500. OTOH you can buy a used JP, or a used PA46 and convert it, total cost about $1M for a reasonable example with the stronger PA46 hull, and it will cost a lot less than a E500 which doesn't exist on the used market.
IMHO this is a tough market to break into. There will be precious few IFR piston owners with the dosh to buy anything at/over $1M. Perhaps 1% can. And I think those who have $1M can also afford $2M or $3M... There seems to be a continuous spectrum from zero to say $300k among what I call normal working people, but the bigger amounts are the sole province of people who have a big business, or have sold a business, or made a fast buck somewhere, etc. And those spending $1M or $2M will be doing their due diligence, and will go for a proven solution (Jetprop, Meridian, TBM, etc) because they (well, perhaps excluding some bankers) have made their money with the application of a lot of care and patience in their business.