Many years ago most of us started out on flexwings because there were very few true 3 axis microlights about although there were hybrids like the eagle for instance , that used a combination of weight shift coupled with rudimentary control surfaces.
The general consensus was that when moving on to GA there was never any problems. Some GA pilots who had ingrained emergency reflexes found it harder to go the other way.
There are shed loads of people that fly both without any problems.