Yes ,normally departure from closest runway and both 3 runways are mixed mode ,except middle runway is only for departure in each morning due to dep aircraft rush hour.
RNAV is accurate enough ,but pilots sometimes made a mistake ,like there is one point named AA151 it is only one minute on upwind after departure ,we used to issued that point ,but pilot sometimes fly to west and made a mistake that is a potential conflict with aircraft dep from west runway.
Before we have RNAV ,we issue heading ,36L heading 330 ,36R heading 360 and 01 heading 060,but now we have RNAV 01 is initial heading 030,that made a dangerous conflict with aircraft from middle runway.