Thanks for your input, chaps. Sprogget, your suggestion about heat got me thinking: my pc has always been on, 24/7 and it's in a corner where ventilation is limited. So now I have a big fan parked next to it and I turn the computer off every night. Now I can run every application all day - even my GPU-roasting flight sim - without crashing....almost. Well, I get the occasional crash, so there must be a bit of damage/instability, but for the most part, she runs all day, hassle-free!