Sure.
If the crankshaft were driven externally at rated speed without combustion taking place (as if an engine is shut down with a windmilling prop), then the master rod bearing sees only centrifugal loads.
But turn on fuel and ignition, and now the power-stroke gas load on the pistons, pushing "down" on the con rods, is in a direction opposite the centrifugal load on the master rod bearing.
Thus the balance between manifold pressure (MAP) and RPM is crucial to long TBO life on these engines.
P&W went through quite an episode of developing the right bearing alloy for the master rod of the R-1830 and the like. I'm sure Wright and Bristol etc. had the same tribulations.