To a degree this is what I have on a little EEE 901 laptop I have. It came with 2 x 4GB very slow SSDs.
The 1st one (drive C) is soldered on the PCB and I am stuck with it. The 2nd one I replaced with a fast 32GB one, and most software has been installed on it (D:).
Unfortunately, the Hibernation file ( = memory size i.e. 1GB in my case) has to stay on C: and that is a limiting factor re how much free space has to be on it, alongside winXP and some other garbage.
Also, the default program installation path is c:\program files and I can't find a way to change that to d:\program files - but this is not a big deal at all.