Out of the current crop of wide bodies, the A330 and A340 (and the upper deck of the A380) are the best choice with 2-4-2 seating ensuring that if you are on the inside (window seat or central) you only have one seat to get across to get to an aisle.
I'm told the cabin crews like this arrangement too when it comes to meal and beverage services.
3 across seating is a pain except in the centre (B777). As I get older I find having to get over 2 seats in order to get out (particularly on night flights where I'm trying not to wake the pax in B-C or H-J) is a feat of athleticism I am no longer able to achieve.
I realise that 3-3 seating is unavoidable in narrow body aircraft with a single aisle but there must surely be some better way for the B747, B777 and lower deck A380?
How about seats facing each-other with common leg room like the old style railway carriages?