VMC,
DA42 (TS) is piston, diesel, so it uses JET-A fuel (it can use diesel-fuel also)
I don't know what others might think, but given your conditions you should be ok to step onto a DA42. I say this bearing in mind you have to get training anyway to get the ME rating.
In terms of speed and anticipation needed I would say a TB20 and a DA42 aren't much different.
In terms of comfort and cabin space... the TB20 is a much nicer a/c, and kinda sexy with the seagull doors.
Why not a Cirrus?
(Never flew one, but I'd love to)
Cheers / Pablo