I have very limited experience in the commercial world. I havn't in the grand scheme of things been employed that long in the commercial world.
However i was told 2 things a long time ago.
1) Never turn down a type rating
2) Never turn down a command.
Now i don't know your exact circumstances and so can't give you a great deal of advice.
But do you currently have command experience?
If not, command on a turboprop is surely more valuable in the long run than F/O ship on a jet (and being a regional i'm guessing an EMB145 or CRJ700 ish type). I'm assuming command time is just as valuable in the US as it is in europe.
Now despite all that I also know first hand how tough it is to be away from family for a long period of time. It really really sucks, but to get my first job a few years ago i really didn't have a choice. But it's been very tough and i'm so glad it's coming to an end.
Just my tuppence worth.