Sorry, I don't work at an airline that operates like that, if the aircraft is legal, why would you turn down the flight?
You say that the aircraft is more unsafe, maybe you are smarter than the aircraft manufacturer?
Once again, "the manufacturer" considers each MEL item IN ISOLATION. There is NO consideration given for multiple MEL items, unless specifically stated. Therefore, ANY combination of multiple MEL items requires the Captain's close scrutiny and consideration.
I have not done it often, but in 11 years of flying the 747 I have refused toatake off due to a combination of MEL items. Generally it's a case of not wanting to delay a schedule, or even pure maintenance laziness, rather than not having the ability to fix it at a particular station. They fix one or more; we go flying.