With 26 years ATC in the USA I would have to agree with 411A, I would expect an automated airliner to follow the approximate track of the runway centerline due to the level of automation. I would expect and protect for a lesser equiped aircraft to drift some due to stong crosswinds based on experiance. When ATC uses runway heading on takeoff or missed approach we have more than enough protected airspace to deal with some heading issues. I would have to say I never had a situation where 30 degrees off would be a issue. If it was that close a turn would have been specified. Also remember until your radar identified the seperation standards are alot greater and that is what the clearance is based on. Once we say radar contact we have a whole lot less space to protect.